(redirected from 3-Hydroxy-3-Methylglutaryl-CoA)
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HMGCR3-Hydroxy-3-Methylglutaryl-CoA (Coenzyme A) Reductase
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1996) and involved in the clearance of circulating and cellular lipids by controlling the expression of lipogenic genes including diacylglycerol acyltransferase (DGAT), 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase and cholesterol 7[alpha]-hydroxylase (CYP7A) (Berger and Moller 2002; Waterman and Zammit 2002; Konig et al.
3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing rho GTPase-induced down-regulation of p27(Kip1).
C50H is increased in 3-methylcrotonyl-CoA carboxylase deficiency, 3-hydroxy-3-methylglutaryl-CoA lyase deficiency, and 3-methylglutaconyl-CoA hydratase deficiency, whereas 2-methyl-3-hydroxybutyrylcarnitine is increased in [beta]-ketothiolase deficiency and 2-methyl-3-hydroxybutyrl-CoA dehydrogenase deficiency (118).
Genes spotted multiple times on different parts of the array include 3-hydroxy-3-methylglutaryl-CoA reductase, glycosylate reductase, choriogenin 2, a clone that shares homology to Unknown protein (GenBank accession no.