Treatments consisted of standard three-dimensional conformal RT (3D-CRT) for the prostate in 74 patients, whole-pelvis RT (WP-RT) followed by 3D conformal prostate boost in seven, and salvage/adjuvant 3D-CRT for the postsurgical site after radical prostatectomy in 23 patients.
Uni- and multi-variate analyses were performed to identify factors predicting LRD after 3D-CRT.
As a preliminary arrangement for changing equipment from 3D-CRT to IMRT, it was essential to conduct a risk assessment for the development of LRD.
Clinical and dosimetric predictors of late rectal syndrome after 3D-CRT for localized prostate cancer: Preliminary results of a multicenter prospective study.
Of the remaining 16, 9 had 3D-CRT (66 cGy, 33 fractions), 5 had intensity-modulated radiation therapy (IMRT) (66 cGy, 33 fractions and 46 cGy, 23 fractions), 1 had 3D-CRT at 79cGy, 42 fractions and 1 patient had 3D-CRT at 50 cGy, 25 fractions.
23) Although the total number of patients who had radiation and cuff erosion in our series was small, 3D-CRT was performed mostly in those who experienced an erosion.
It is possible that over the next 10 years more patients will be treated with IMRT rather than 3D-CRT, which may reduce the incidence of cuff erosion.
The use of 3D-CRT has been investigated as a treatment for several head and neck cancers, including skull base tumors.
18] Gademann et al reported promising results with 3D-CRT in 195 patients who had tumors of the head, neck, or brain.
Latz et al described the outcomes of 13 patients whose clival chordomas were treated with 3D-CRT to a median dose of 70 Gy.