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The most common cART regimens were ABC + 3TC + EFV (n=165, 32.
TDF was dosed at 300 mg/d, 3TC at 300 mg/d, and EFV at 600 mg/d.
For patients who were receiving d4T, 3TC and EFV who have a detectable VL, clinicians should do additional adherence counselling and repeat the VL in 2-3 months.
For 3TC and d4T, the mobile phase was a mixture of 10 mM phosphate buffer, pH 6.
Patients who are co-infected with hepatitis B and HIV should normally be treated with TDF and 3TC or FTC, even if there is evidence of mutation in the HIV genome associated with resistance to these agents .
The response rate among patients not receiving 3TC or FTC in their background treatment regimen was 80% versus 25% on placebo.
On this regimen we can often find a virus that has only learned to resist 3TC, or 3TC and nelfinavir.
Researchers reported that significantly more antiretroviral-naive patients taking Sustiva in combination with AZT and 3TC exhibited suppressed levels of HIV to below quantifiable levels (less than 400 copies/mL) than people taking indinavir in combination with AZT and 3TC.
In each study patients took two older drugs, AZT and 3TC, in combination with a member of a new class of drugs known as protease inhibitors.
The early development of 3TC was done by the late Bernard Belleau, a former McGill University Professor and world renowned chemist.
Avexa's Phase III trial has been conducted with more than 130 sites worldwide and compares ATC to 3TC in drug-resistant HIV patients.
Doravirine (MK1439), an investigational NNRTI being evaluated by Merck for the treatment of HIV-1 infection, is being evaluated in several ongoing clinical trials as a once-daily fixed dose combination with 3TC and TDF or individually for use in combination with other antiretroviral agents.
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