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Bu ustunlugun, TSA'larin hem 5HT hem NA uzerine etkili olmasiyla baglantilanmasi, direncli depresyonlarda coklu farmakolojik mekanizmalan birlestirme dusuncesini desteklemektedir.
Calling a group of drugs specific serotonin reuptake inhibitors (SSRIs) is a bit of public relations: they have effects not only on all of the subtypes of 5HT receptors, but also on DA receptors (occasionally causing akathisia and tardive movement disorders) and GABA receptors (causing disinhibition), not just on the [5HT.
Besides 5HT reuptake inhibition, fluoxetine possesses some NE reuptake blockade and 5HT2c agonist action (20).
OBJECTIVES: We exposed neonatal rats to daily doses of diazinon or parathion on postnatal days (PND)1-4 and evaluated 5HT receptors and the 5HT transporter in brainstem and forebrain on PND5, focusing on doses of each agent below the maximum tolerated dose and spanning the threshold for cholinesterase inhibition: 0.
Address for correspondence: Oliver Morgan, Health Protection Agency, Communicable Disease Surveillance Centre, 61 Colindale Ave, London NW9 5HT, UK; email: omorgan@ bigfoot.
45pm Venue: Courtyard Marriott Hotel Reading RG7 5HT Cost: 15 [pounds sterling] members/students, 25 [pounds sterling] guests Contact: CIMA Courses & Conferences, T: 020 8849 2244, E: mastercourses@cimaglobal.
The process is believed to start when a chemical called serotonin,or 5HT,is released into the bloodstream from storage sites in the body, resulting in changes in the neurotransmitters and blood vessels in the brain.
It is also possible the 5HT may be helpful for myoclonus that is caused by other factors.
Seven 5HT receptor classes with subtypes are so far known.