A2ARAlpha-2 Adrenergic Receptors
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According to the company, the A2AR natural ligand, extracellular adenosine, is locally produced at the sites of inflammation and has been characterized for decades as a "brake for inflammation.
The combination of our industry leading allosteric modulator drug discovery platform with Viva's cutting-edge structural biology expertise is expected to facilitate the development of a selective and potent oral small molecule for the activation of A2AR, a compelling new mechanism of action to address multiple inflammatory diseases, including certain rare disease indications with significant unmet medical needs.
Under the terms of the agreement, Viva Biotech will provide a fully-integrated structural biology discovery service to Addex to deliver high resolution crystal structures of A2AR in complex with positive allosteric modulators (PAMs) that were identified using Addex proprietary HTS technologies.