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A431

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AcronymDefinition
A431human epidermoid carcinoma cells


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Characterization of the Ah receptor and aryl hydrocarbon hydroxylase induction by 2,3,7,8-tetrachlorodibenzo-p-dioxin and benz(a)anthracene in the human A431 squamous cell carcinoma line.
The immunotoxin had negligible activity against A431 cells, which do not express mesothelin (median inhibitory concentration > 100 ng/mL).
Using this system, we found that FIR inhibits tumor growth in the A431 tumorigenesis model mouse by inhibiting the expression of matrix metalloprotease-1, 9, 10 and 13.
 
 
 
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