AAVS1Adeno-Associated Virus Integration Site 1
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Similar to what the Rosa26 locus has done for transgenic research in mice, we believe the AAVS1 locus will provide a 'safe harbor' site from which to study gene function and expression.
The CompoZr Targeted Integration Kit uses a ZFN to target the transgene specifically into the AAVS1 locus in the human genome leading to mono- or bi-allelic insertions enabling the stable expression and study of transgenes in cell lines where the number of integrants and the locus of integration is controlled by the researcher.
In a report published in the October issue of Journal of Virology, Avigen researchers and their collaborators at Jichi Medical School in Tochigi, Japan developed a model system to demonstrate the integration of AAV at AAVS1 on human chromosome 19.