ABCA1


Also found in: Medical.
AcronymDefinition
ABCA1ATP (Adenosine Triphosphate) Binding Cassette Transporter A1
References in periodicals archive ?
3] Nonstandard abbreviations: HDL-C, high-density-lipoprotein cholesterol; CVD, cardiovascular disease; apo, apolipoprotein; ABCA1, ATP-binding cassette transporter 1; HDL-P, HDL particles; NMR, nuclear magnetic resonance; IMA, ion mobility analysis; ESI, electrospray ionization; rHDL, reconstituted HDL; CCVD, carotid cerebrovascular disease; pI, isoelectric point; S-HDL, small HDL; M-HDL, medium HDL; L-HDL, large HDL.
Deleting the ABCA1 gene in young macrophages caused them to behave like old macrophages.
Modifying apolipoprotein A-I by malondialdehyde, but not by an array of other reactive carbonyls, blocks cholesterol efflux by the ABCA1 pathway.
If ABCA1 function is lost in cancer cells, cholesterol builds up in the cells' mitochondria, making their membranes more rigid.
Also, additional data from the literature indicating unaltered ABCA1 expression, another member of ATP dependent MRPs family in cholesterol loaded cytoresistant tubule cells (Zager et al.
Monocyte/macrophage expression of ABCA1 has minimal contribution to plasma HDL levels.
ABCA1, for example, is responsible for transferring cholesterol, cholesteryl esters and other lipids from the inner to the outer leaflet of the plasma membrane from which they can be captured by apolipoprotein A-I to form HDL.
We conclude that plasma HDL levels and ABCA1 activity do not control net cholesterol transport from the periphery via the liver into the bile, indicating the importance of HDL in reverse cholesterol transport requires re-evaluation.
Another mechanism in the reverse pathway involves the ABCA1 tranporter.
LXR agonists have been documented to enhance expression of apo A1, CETP, and ABCA1 and ABCG1, which are involved in promoting cellular efflux of cholesterol from the periphery, which is carried by HDL particles to the liver for conversion into bile salts.
In mice, administration of VTP-4 resulted in significant increases of the ABCA1 biomarker with all doses tested.