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And they found that mice's capillaries function the same way humans' do when it comes to their response to ADAM17.
EGFR ligand release involves a pathway in which Src activates phosphatidylinositol 3-kinase (PI3K), leading to phosphoinositide-dependent kinase 1 activation and phosphorylation of ADAM17.
Cell line and mouse experiments showed that blocking production of ADAM17 with small interfering RNA or with an inhibitor of the protease blocked the formation of colorectal cancer stem cells.
2) We now know that there are many sheddases, although the most important appear to fall into 2 classes, both of which are zinc-dependent proteases: ADAM (a disintegrin and metalloproteinase) proteases, such as ADAM17 and ADAM10, and MMPs (matrix metalloproteases) (Fig.
The role of ADAM10 and ADAM17 in the ectodomain shedding of angiotensin converting enzyme and the amyloid precursor protein.
A Multicenter Phase Ib Study of the Safety, Pharmacokinetics, Biological Activity and Clinical Efficacy of INCB7839, a Potent and Selective Inhibitor of ADAM10 and ADAM17
Liver protective effect of ursodeoxycholic acid includes regulation of ADAM17 activity.
They also reported that this EPCR protein was indeed synthesized and secreted, and that sEPCR was generated via ADAM17 cleavage (24).
Weinmaster, "Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling," Molecular and Cellular Biology, vol.
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- ADAM-TS 3
- ADAM-TS 4
- ADAM-TS 5
- ADAM-TS 6
- ADAM-TS 7
- ADAM-TS 8
- ADAM-TS 9
- Adam/Eve Principle
- Adam’s apple
- Adam’s triad