ADAMTSA Disintegrin-Like and Metalloproteinase with Thrombospondin
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A disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motifs: the ADAMTS family.
Proteoglycan degradation by the ADAMTS family of proteinases.
Cloning, expression analysis, and structural characterization of seven novel human ADAMTSs, a family of metalloproteinases with disintegrin and thrombospondin-1 domains.
2]-induced alterations in apoptosis rate as well as the differences in aggrecan degradation in OUMS-27 cells using a viability test, comet assay, Caspase-1, and ADAMTS enzymes.
2] in terms of DNA damage, cell viability, apoptosis, and ADAMTS genes in OUMS-27 cells for the first time.
vWF-CP is a member of the ADAMTS family of metalloprotease enzymes and is designated ADAMTS-13.
ABBREVATIONS: ADAMTS = a disintegrin-like and metalloprotease domain with thrombospondin type motifs; HUS = hemolytic-uremic syndrome; LD = lactate dehydrogenase; MAHA = microangiopathic hemolytic anemia; PT = prothrombin times; PTT = partial thromboplastin times; TMA = thrombotic microangiopathy; TT = thrombin times; TTP = thrombotic thrombocytopenic purpura; ULVWF = ultralarge VWF; VTEC = verotoxin-producing Ecoli; VWF = Von Willebrand factor; VWF-cp = VWF-cleaving protease.
FRETS-VWF73, a first fluorogenic substrate for ADAMTS 13 assay.
Enzymes such as the MMPs, which can degrade the major components of the extracellular matrix, and some members of the ADAMTS family, which mediates mostly cartilage aggrecan loss, remain at this time the major targets for DMOADs.
Synovitis Antiinflammatory therapies Table 2 Tissue Specific Therapeutic Targets for DMOAD Development I Cartilage Inhibiting Catabolism * Protease inhibitors of MMP and ADAMTS * Inducible nitric oxide synthase (iNOS) inhibitor * Cell-signaling pathway inhibitors: MAPK, JNK, p38, ERK1/2, etc.
17) They also inhibit the cleavage of ULVWF by ADAMTS 13.