Detection of ADH2, ADH3, and ALDH2 was performed using previously described methods [Nakamura et al.
Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism.
Linkage disequifibrium at the ADH2
and ADH3 loci and risk of alcoholism.
In this study, we examined whether the changes in blood pressure, serum lipids, and uric acid associated with alcohol consumption varied in relation to the polymorphisms in ADH2
Table 1 Alcohol Dehydrogenase (ADH) Genes and Proteins Official Gene Nonstandard Name* Old Name ([dagger]) Name ([double dagger]) ADH1A ADH1 ADH1A ADH1B ADH2
ADH1B ADH1C ADH3 ADH1C ADH4 ADH4 ADH2
ADH5 ADH5 ADH3 ADH6 ADH6 ADH5 ADH7 ADH7 ADH4 Official Gene Name* Sequence ([section]) Protein Class ([paragraph]) ADH1A NM_000667 [alpha] I ADH1B NM_000668 [beta] I ADH1C NM_000669 [gamma] I ADH4 NM_000670 [pi] II ADH5 NM_000671 [chi] III ADH6 NM_000672 ADH6 V ADH7 NM_000673 [sigma] IV *Gene symbol approved by the Human Genome Organization (HUGO) Gene Nomenclature Committee (www.
allele was amplified as reported previously (11).
2)], each ADH2
genotype based on nail clippings was completely consistent with that based on a blood sample.
and alcohol-related phenotypes in Ashkenazic Jewish American college students.
2) ADH1B and ADH1C were formerly called ADH2
and ADH3 respectively (for more information, see the accompanying article by Edenberg).
An earlier case-control study, conducted in Chinese patients, analyzed ADH2
, ADH3, ALDH2, and CYP2E1 genes in patients with acute alcoholic pancreatitis, in alcoholic patients without organ damage, in patients with pancreatic disease of nonalcoholic origin, and in patients with alcoholic liver disease.
In view of these differences between the two subject populations, it is of interest that both studies found some evidence for a protective gene in the same region of chromosome 4 (which includes, for example, the ADH2
and ADH3 genes).
gene polymorphism's are determinants of alcohol pharmacokinetics.