Nevertheless, some studies have documented minor histopathologic differences between AIDS-KS and non-HIV-associated KS cases, namely, that mitoses and cellular anaplasia are more common in HIV-negative patients, whereas AIDS-KS lesions tend to display more extensive dissecting vessels.
In rare instances, AIDS-KS lesions may harbor concomitant pathologic findings, usually an opportunistic pathogen (eg, cryptococcosis, mycobacterial granulomas, or molluscum contagiosum).
Lymphedematous AIDS-KS may also be associated with exophytic dermal fibroma-like nodules.
A goal of our study was to determine the HHV-8 genotypes for a series of classic KS or AIDS-KS cases in Peru.
Two AIDS-KS mestizo patients (Figure 1) were thus found to be infected by typical E subtype HHV-8 strains: a 51-year-old man with a tumor on his neck and a 24-yearold man with multiple tumors on the upper limbs.
Indeed, in 2 AIDS-KS patients, an E genotype was characterized in the tumor lesions.
This study included planer, single photon emission computed tomography (SPECT) and neck pinhole (P)-SPECT in selected patients with KS (classic KS, AIDS-KS
and transplantation-associated KS).
A total of 241 patients with advanced AIDS-KS
were enrolled in the trial.
DOXIL is currently in widespread use throughout the United Sates and we look forward to making it available to AIDS-KS
patients and their physicians in Europe," said SEQUUS President and Chief Operating Officer Scott Minick.
The annual market for second-line therapy of AIDS-KS
is estimated at $12 to $15 million and, thus, the $4.
The MAAs also seek authorization to use the drug in treating AIDS-KS
Food and Drug Administration requesting approval to use DOX-SL in the treatment of AIDS-KS
patients who have failed or cannot tolerate conventional combination chemotherapy.