This center confirmed that the clinical picture and histopathological specimen were most consistent with AITL and recommended a chemotherapy regimen of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) and vorinostat.
AITL is a rare hematologic disease that classically presents with lymphadenopathy, hepatosplenomegaly, hypergammaglobulinemia, anemia, and B-type symptoms and is distinguished by distinctive lymph node architecture disruption.
Profiling of ALK+ ALCL and ALK- ALCL by The International T-Cell Lymphoma Project, and comparison with AITL
, adult T-cell leukemia/lymphoma, and PTCL-NOS, revealed that ALK+ ALCL could be separated from these entities at the molecular level.
On the other hand, Lee and colleagues  did not find an association between EBV positiviry and survival in Korean AITL
Baseline characteristics presented at ICML show the average patient age to be 58 years with slightly more men enrolled in the registry to date [44 men (59%) and 30 female (41%)]; the most common PTCL subtypes are PTCL-NOS (18 of 74 patients; 24%), ALCL (13 of 74 patients; 18%), AITL
(11 of 74 patients; 15%), T/NK cell lymphoma, nasal type (7 of 74 patients; 10 %), and transformed mycosis fungoides (7 of 74 patients; 10%).
PTCL is a diverse group of aggressive, mature T and NK (natural killer) cell non-Hodgkin lymphomas which include PTCL-NOS (PTCL not otherwise specified), AITL
(angioimmunoblastic T-cell lymphoma), and ALCL (anaplastic large-cell lymphoma).