The results were similarly null when lead measures were analyzed as continuous variables either untransformed or log transformed, after additional adjustment for ALAD
genotype or use of beta-blockers and/or calcium channel blockers, and in subgroups defined by ALAD
genotype or beta-blocker/calcium channel blocker medication use (data not shown).
gene contains two codominant alleles: ALAD
-1 and ALAD
Zn is an essential element for humans and animals due to its role as a constituent of metalloenzymes such as alcohol dehydrogenase, alkaline phosphatase, carbonic anhydrase, superoxide dismutase (a Zn-copper metalloenzyme), ALAD
and DNA and RNA polymerases.
Wetmur of the Mount Sinai School of Medicine for providing the nested primers for ALAD
Only Rsa39488 subgroups had significant differences in PbB, with means of ALAD
1-2, and ALAD
2-2 being 21.
genotype--based on the ALAD
1 and ALAD
2 alleles--was determined for each patient and each control subject.
gene codes for the enzyme [delta]-aminolevulinic acid dehydratase (ALAD
), which catalyzes the second step of heme synthesis involving the condensation of two molecules of aminolevulinic acid (ALA) to form porphobilinogen.
Most recently, Bernard has found thataluminum also inhibits ALAD
activity in people undergoing blood dialysis.
Failure of normal functioning of ALAD
to convert 2 molecules of ALA into prophobilinogen decreases heme formation.
The fact that the ALA/PBG ratio was highly increased (10-fold that of normal), concomitantly with the finding that the inhibited activity (87%) of ALA dehydratase (ALAD
) in erythrocytes (16,17) was induced 10-fold in the presence of zinc and cysteine (Table 1), led to the suspicion of LP rather than hereditary ALAD
have reported two text errors in their article "Modification by ALAD
of the Association between Blood Lead and Blood Pressure in the U.
Bondy (30) investigated the effects of various organic metal compounds on ALAD
activity and reported that triethyl lead chloride has the same potency as lead nitrate in inhibiting ALAD
both in vitro and in vivo.