So it appears that ALK
can give cells a growth advantage in contexts as diverse as human cancers and developing fruit flies," added Gould.
The abnormality in ALK
that arises in NSCLC is not, strictly speaking, a mutation rather, it results from a chromosomal rearrangement, in which the structure of a chromosome - the scaffolding of genetic material - is altered.
Assays like our Insight ALK
Screen are important advancements in this evolving cancer landscape.
GenASIs Scan & Analysis offers clinicians a way to automatically perform genetic analysis on tissue samples, stained with the Abbott ALK
[TM] probe kit, and identify the ALK
Chugai Pharmaceutical's selective ALK
inhibitor CH5424802 produced an overall response rate of 85%, including 3 complete responses and 36 partial responses among 46 patients with advanced or metastatic ALK
-positive NSCLC previously treated with one or more alemotherapies, but not with ALK
Several methods are available to detect ALK
rearrangements, including break-apart fluorescence in situ hybridization (FISH), immunohistochemistry (IHC), and reverse transcription-polymerase chain reaction (RT-PCR).
gene promotes lung cancer by encoding the production of ALK
protein, an enzyme that is critical for the growth and development of cancer cells.
GenASIs further adds the ability to perform "walk away" automated genetic tissue scanning for ALK
using an 81 slide continues scanning robot.
The third poster at ECC2015 reported results from a pilot study demonstrating the high sensitivity and specificity of IHC as a screening tool for ALK
The advanced courses are based on the basic courses and are aimed at ALK
employees with practical experience of at least 18 months and a lot of customer contact or for ALK
employees with managerial responsibilities.
para]]"FDA approval of the VENTANA ALK
(D5F3) CDx Assay is a tremendous accomplishment," says Mary Padilla, MD Senior Director of Pathology and Medical Director for Ventana Companion Diagnostics.
gene is activated through chromosomal rearrangements, most notably with echinoderm microtubuleassociated proteinlike 4 (EML4) forming an aberrant fusion gene.