results went a step further, however, and for the first time showed the clinical impact of this muted effect on blood pressure, he said.
The debate over the two classes was brought into the spotlight by the ALLHAT
trial, which concluded that diuretics are superior to the ACE inhibitor lisinopril and the CCB amlodipine in preventing major cardiovascular events.
Collaborative Research Group, Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: The antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT
Haywood of the ALLHAT
Collaborative Group, Los Angeles.
, with 42,448 participants, is the largest randomized, double-blind, active-controlled hypertension trial ever performed.
Therefore, no drug--not even chlorthalidone--is superior, based on the ALLHAT
The ADA (2012) guidelines, the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT
Officers and Coordinators for the ALLHAT
Collaborative Research Group, 2002), and the United Kingdom Prospective Diabetes Study Group (1998) findings support the use of diuretics, beta blockers, angiotensin receptor blockers, and angiotensin-converting enzyme inhibitors or calcium channel blockers in the management of hypertension in patients with diabetes.
A retrospective analysis of data on 31,896 participants in ALLHAT
(the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial) showed that during a mean 4.
An additional 4 years of follow-up for mortality because of cancer was available through national databases after ALLHAT
Much like the MATCH study, ALLHAT
researchers believed that certain patients would do better with certain medication/treatment types, but found that they were wrong.
Collaborative Research Group 2002; Collins, Peto, and Armitage 2002; Heart Protection Study Collaborative Group 2002; National Cholesterol Education Program (NCEP) 2002; Simes et al.
Institute's so-called ALLHAT
(Antihypertensive and Lipid-Lowering