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ALLHATAntihypertensive and Lipid-Lowering Treatment To Prevent Heart Attack Trial
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The ALLHAT results went a step further, however, and for the first time showed the clinical impact of this muted effect on blood pressure, he said.
The debate over the two classes was brought into the spotlight by the ALLHAT trial, which concluded that diuretics are superior to the ACE inhibitor lisinopril and the CCB amlodipine in preventing major cardiovascular events.
ALLHAT Collaborative Research Group, Major cardiovascular events in hypertensive patients randomized to doxazosin vs chlorthalidone: The antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT).
Haywood of the ALLHAT Collaborative Group, Los Angeles.
The ALLHAT, with 42,448 participants, is the largest randomized, double-blind, active-controlled hypertension trial ever performed.
Therefore, no drug--not even chlorthalidone--is superior, based on the ALLHAT evidence.
The ADA (2012) guidelines, the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group, 2002), and the United Kingdom Prospective Diabetes Study Group (1998) findings support the use of diuretics, beta blockers, angiotensin receptor blockers, and angiotensin-converting enzyme inhibitors or calcium channel blockers in the management of hypertension in patients with diabetes.
A retrospective analysis of data on 31,896 participants in ALLHAT (the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial) showed that during a mean 4.
An additional 4 years of follow-up for mortality because of cancer was available through national databases after ALLHAT ended.
Much like the MATCH study, ALLHAT researchers believed that certain patients would do better with certain medication/treatment types, but found that they were wrong.
2001; ALLHAT Collaborative Research Group 2002; Collins, Peto, and Armitage 2002; Heart Protection Study Collaborative Group 2002; National Cholesterol Education Program (NCEP) 2002; Simes et al.
Institute's so-called ALLHAT (Antihypertensive and Lipid-Lowering