AMA1

AcronymDefinition
AMA1Apical Membrane Antigen 1
AMA1Autonomous Maintenance in Aspergillus (plasmids)
References in periodicals archive ?
A team led by led by Sheetij Dutta, from the Walter Reed Army Institute of Research, USA, focused on a protein called AMA1 needed by the Plasmodium falciparum parasite to invade blood cells and cause disease.
The challenge with the malaria parasite in general and its AMA1 surface protein in particular is that both exist as multiple strains.
To explore the potential for a more broadly protective vaccine, the scientists tested different cocktails of AMA1 from different parasite strains for their ability to elicit a diverse range of antibodies that are active in parasite inhibition assays.
They confirmed that a cocktail of AMA1 proteins from three different parasite strains was better than one or two, and one they call Quadvax, which contained AMA1 proteins derived from four different strains, led to an antibody response that was broader than the sum of strain-specific antibodies elicited by the four individual strains.
Impact of a Plasmodium falciparum AMA1 vaccine on antibody responses in adult Malians.
The team said a vaccine causing anti-bodies to attack AMA1 could be powerful, because the protein occurs during two critical life stages of the parasite.