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AMACRAlpha-Methylacyl-CoA Racemase
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CK7, AMACR, and TFE3 were used in the IHC analysis.
It is usually negative for vimentin, carbonic anhydrase IX, and AMACR (Table 1).
Immunohistochemistry, especially p63 and PAX2, may be useful in resolving this differential diagnosis, as urothelial carcinomas with deceptively bland features (nested and/or urothelial carcinoma with small tubules) are strongly positive for CK7, p63, and 34PE12, while nephrogenic adenoma is positive with AMACR, PAX2, and CK7, variably positive with 34PE12, and negative with p63.
Tumour cells are immunopositive for CK19 (a: x200), vimentin (b: x200), CD10 (c: x400) and AMACR (d: x200).
Immunohistochemical staining on FNA cell block preparations showed positive staining for E-Cadherin, CD10 (Figure 4), AMACR (Figure 5), and cytokeratin AE1/AE3.
ise AMACR 'negatif' oldugunu dolayisiyla AMACR pozitifliginin karsinomatoz degisimin erken temsilcisi olabilecegini belirtmislerdir.
Only by using LCM were we able to uncover these deletions in the AMACR sequence," Dr.
However, in contrast to basal cell proliferations, the lack of HMWCK expression as well as positive AMACR and PSA expression confirms the secretory nature of the cells in p63-positive PCas.
AMACR breaks down branched-chain fatty acids, a type of molecule only found in animals that eat plants.
AMACR (a methylacyl-CoA racemase) (12), HPN [hepsin (transmembrane protease, serine 1)] (13), and ZWINT (ZW10 interactor) (14) are all associated with prostate cancer in the scientific literature but are known to not be secreted and were correctly identified as such by our methods.
He is a recognized leader in the field and has led the characterization of a number of biomarkers of prostate cancer including AMACR, EZH2, and hepsin.