The senior tranche of AOMT
2017-3 was oversubscribed and received AAA-ratings from both Fitch and DBRS, similar to its two previous securitizations in 2017.
The traditional treatment for AOM (not COME) has been antibiotics, while in AOMT
there is a portal for delivery directly to the middle ear so that a local antibiotic and cortisone drop combination can be adequately administered--giving a much higher dose of antibiotic to the affected area.
In a study published in late 2006, Ruohola et al evaluated 79 children with AOMT
within 48 hours of the onset of otorrhea: 73% of these children were evaluated within 24 hours.
Comment: Approval was based on a clinical trial of 400 children with AOMT
aged 6 months to 12 years, and a second study of 537 people with acute otitis externa aged 6 months to adult, including elderly subjects.
The largest collection of (potential) pathogens isolated from external otitis (2) or AOMT
(3) has been accumulated and analyzed by Alcon Laboratories during clinical trials of their otic preparations.
The localization of these drops to the external ear in otitis externa and to the middle ear and mastoid in AOMT
and CSOM reduces the possibility that the microflora in the nasopharynx will become altered.
New otic quinolone formulations are being investigated as a possible treatment for AOMT
, otitis externa, otitis media with a perforated tympanic membrane, and chronic suppurative otitis media.
1) So while AOM is associated with the usual respiratory pathogens, AOMT
is linked to those as well as to organisms that are associated with water and skin.
For example, in a recent AOMT
study that we conducted, a Juhn Tym-Tap device was placed at the lumen of the tympanostomy tube to collect the otorrhea.
Deitmer: A diagnosis of AOMT
requires that the tube be patent.
Ototopical quinolones are so effective in treating AOMT
that systemic therapy is rarely needed.
In 2003, they reported their comparison of topical ciprofloxacin/dexamethasone and topical ciprofloxacin alone in 201 children with AOMT