Also found in: Medical, Wikipedia.
APAF1Apoptotic Protease Activating Factor 1 (antibodies)
References in periodicals archive ?
Importantly, APAF1 and MAP2K4, together with 2 other upregulated genes, deleted in liver cancer 1 (DLC1) and N-myristoyltransferase 1 (NMT1), participate in the cytoplasmic/mitochondrial transport of the proapoptotic proteins Bid, Bmf, and Bim.
4] Human genes: APAF1, apoptotic peptidase activating factor 1; MAP2K4, mitogen-activated protein kinase kinase 4; TP53, tumor protein p53; DLC1, deleted in liver cancer 1; NMT1, N-myristoyltransferase 1; EF2S1, eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa; DYNLL1, dynein, light chain, LC8-type 1.
More specifically, the invention relates to germline mutations in the APAF1 gene and their use in the diagnosis of predisposition to depression.