AQP2Aquaporin2 (membrane channel proteins found in cells of the kidney collecting duct)
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In contrast, diabetes upregulated AQP2 and AQP3 expressions significantly in kidney compared with control group.
Effect of Citrullus colocynthis and Insulin Administration on Immunohistochemical Expression of Insulin, GLUT-2, and AQP2 in Pancreas and Kidney of Diabetic Rats
While the function of the coelacanth Aqp2-like channels remains unknown, the physiological role of the Aqp2-like channels in lungfishes is to promote antidiuresis during terrestrial estivation in a manner entirely synonymous with the arginine-vasoticin-induced regulation of AQP2 channels in the kidneys of modern tetrapods (Konno et al.
AQP2 was expressed throughout the cytoplasm of the epithelium and detrusor muscle layer, whereas AQP3 was expressed throughout the cell membrane of the urothelium and not in the cell cytoplasm (Fig.
Focus on "Calcineurin-NFATc signaling pathway regulates AQP2 expression in response to calcium signals and osmotic stress.
Studies in rats have demonstrated that treatment with high-dose lithium results in dramatically reduced whole kidney abundance of AQP2 (4).
26-28) Such studies have implicated the increased expression of AQP2 in the pathogenesis of several conditions of volume overload, including congestive heart failure (CHF), pulmonary edema, and liver cirrhosis.
Diversas mutaciones congenitas en el gen que codifica AQP2 y que inducen una alteracion en las propiedades fundamentales de la proteina, pueden producir un tipo de diabetes insipida nefrogenica (45), condicion caracterizada por poliuria e incapacidad para concentrar la orina, con las consecuentes perdida incrementada de liquidos y deshidratacion, las cuales originan polidipsia compensatoria.
Several research assays for urinary AQP2 are in the enzyme immunoassay format and could be added to the arsenal of clinical assays, once the clinical utility of detecting elevated levels of AQP2 has been established.
In the rat and stallion testis, interstitial Leydig cells express AQPO (Table 1), whereas AQP2 and -5 have also been detected in stallion Leydig cells.
AQP6vs, AQP2 and/or AQP6ub are also expressed in these epithelial cells and are translocated to the apical membrane in response to arginine vasotocin, thereby regulating water absorption/reabsorption.
AQP2 is the primary water pathway for apical water flux in the principal collecting duct cells of rat; AQP3 and AQP4 are the primary basolateral water channels.