The targeted mRNAs of has-miR-429 and has-miR-5088, DPP4, SERPING1, and AQP3
were validated to be downregulated in the new RIF samples in our previous report.
In contrast, diabetes upregulated AQP2 and AQP3
expressions significantly in kidney compared with control group.
As a topical hydrating ingredient, Diffuporine (INCI name: Acetyl hexapeptide-37) protects against dehydration by activating the human AQP3
promoter and inducing its protein transcription, which improves the water flux to the SC.
AQP1 was reported to be selectively expressed in the microvasculature, and AQP2 and AQP3
are commonly expressed in epithelial cells in various organs.
50, 51) Atraves de uma via metabolica conhecida pela sigla PI3K/Akt/mTOR (Phosphatidylinositol 3-Kinase/Akt/mammalian target of rapamycin), e considerando que o tecido adiposo constitui uma fonte primordial de glicerol via AQP7, (49, 53) relatos mais recentes tem evidenciado que as aquagliceroporinas (em particular AQP3
e AQP7) parecem facilitar o efluxo de glicerol a partir do tecido adiposo, ao mesmo tempo em que podem reduzir o influxo de glicerol para o interior dos hepatocitos via AQP9, prevenindo o excesso de lipidios e o subsequente agravamento da hiperglicemia na obesidade humana.
Other AQP channels, designated AQP3
and AQP4, are always present (constitutive) on the plasma side of the CD cells and facilitate the unregulated exodus of water from these cells (Figure 3B).
Es expresada en membranas basolaterales de TDR y TCR (46), coexistiendo con AQP2 en el mismo tipo de celulas; la funcion de ambas acuaporinas esta acoplada, pues AQP3
es la responsable de la permeabilidad al agua de la membrana basolateral (35).
Twenty-one family members were screened for AQP3
, including 8 affected members and 13 unaffected members.
Conversely, the eutherian water- and glycerol-transporting aquaporins (aquaglyceroporins, Glps) represented by AQP3
, -7, -9, and -10, which range in size from 31.
Disruption of cyclooxygenase-2 prevents downregulation of cortical AQP2 and AQP3
in response to bilateral ureteral obstruction in the mouse.
Although some AhR target genes such as NQOl, SOS1 (son of seven-less homolog 1), and AQP3
(aquaporin 3) decreased 6 months after surgery, CYP1B1 and CYP1A1 did not vary significantly.
17,18,41-44) Studies of patients without functional AQP3
have shown decreased transport of glycerol in RBCs.