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ARF6ADP (Adenosine Diphosphate)-Ribosylation Factor 6 (biochemistry)
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FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex.
However, CT or pentameric CTB may be endocytosed, depending on cell type, either through caveolin-coated vesicles, clathrin-coated vesicles or by the so-called Arf6 endocytic pathway.
Genetic studies have implicated different ARFs in diverse growth processes including embryogenesis (ARF5/MONPTEROS, ARF17), root (ARF7/NPH4, ARF10, ARF16, ARF19) and floral development (ARF1, ARF2, ARF3/ETT1N, ARF6, ARF8), and senescence (ARF2).