Although front-line combination chemotherapy can result in durable response rates, up to 30 percent of these patients relapse or are refractory to front-line treatment and have few therapeutic options beyond ASCT
For patients who are newly diagnosed with multiple myeloma and eligible for ASCT
, key treatment goals are to delay disease progression and ultimately achieve long-term control over multiple myeloma.
Considering that over half of patients relapse within 2 to 3 years after ASCT
trials have been conducted to assess whether maintenance therapy following ASCT
could enable more durable remissions.
is the standard of care following failure of frontline chemotherapy in Hodgkin lymphoma, we know that many patients will unfortunately see their disease return.
These and other findings from the study led the study researchers to conclude that "standard-dose ZEVALIN combined with BEAM high-dose chemotherapy is safe and possibly more effective than BEAM alone as conditioning regimen for ASCT
in the era of rituximab-containing chemotherapy regimens.
In addition, the European Medicines Agency has granted accelerated assessment to the Marketing Authorization Application for Kymriah for the treatment of children and young adults with r/r B-cell acute lymphoblastic leukemia, or ALL, and for adult patients with r/r DLBCL who are ineligible for ASCT
In addition, the European Medicines Agency (EMA) has granted accelerated assessment to the Marketing Authorization Application (MAA) for Kymriah for the treatment of children and young adults with r/r B-cell acute lymphoblastic leukemia (ALL) and for adult patients with r/r DLBCL who are ineligible for ASCT
, invasive fungal infection [IFI] usually occurs in pre-engraftment period however can happen after count recovery as well.
In the report of the European Society for Blood and Marrow Transplantation (EBMT) study, which included 693 patients followed-up for at least 15 years, the outcomes of ASCT
for FL are presented (15).
In conclusion, with the onset of novel agents and widespread use of ASCT
, the MM patients' lifespan had been prolonged.
Notably, brentuximab was shown in randomized clinical trials to significantly improve progression free survival in patients with Hodgkin's lymphoma who have risk factors for relapse or progression after ASCT
In addition, GlobalData epidemiologists provide a 10-year epidemiological forecast for the five-year diagnosed prevalent cases of HL, as well as the number of HL diagnosed incident cases refractory to chemo- and radiation therapy, the number of HL diagnosed incident cases who received autologous stem cell transplantation (ASCT
), and HL diagnosed incident cases refractory to ASCT
from 2014-2024 in these markets.