6) These observations, in conjunction with the known prevalence of premature ASCVD
in SLE patients, emphasize the double jeopardy for young females with SLE who are particularly vulnerable to under-diagnosis and inadequate treatment.
there are approximately 11 million people with ASCVD
and/or familial hypercholesterolemia (FH), who have uncontrolled levels of LDL-C over 70 mg/dL, despite treatment with statins or other cholesterol-lowering therapies.
Moreover, the model estimated that statin therapy would still be cost effective if even more lenient ASCVD
risk thresholds--3%-4% were--used.
without clinical ASCVD
or diabetes with an LDL-C of 1.
Muntner presented a new analysis in which the ASCVD
risk estimator was applied to patients in REGARDS (Reasons for Geographic and Racial Differences in Stroke), a prospective, observational, population-based study of more than 30,000 U.
An even stronger relationship between traditional ASCVD
risk factors and coronary diameter change in response to ACh became apparent in this study.
Grundy, "the metabolic syndrome consists of a constellation of 'metabolic risk factors' for ASCVD
[atherosclerotic cardiovascular disease] that associate with obesity, namely, atherogenic dyslipidemia, increased blood pressure, increased glucose, a prothrombotic state, and a proinflammatory state" (1).
Some investigators and clinicians have surmised that diagnosis of the metabolic syndrome carries with it a relatively high risk for ASCVD
in the short term.
Ten-year follow-up of the two cohorts identified 739 ASCVD
events, of which more than 500 were "excess"; the people in the two cohorts had substantially more ASCVD
events than would have been predicted by their risk factors alone.
Furthermore, according to the risk calculator, the patient has a 50% lifetime risk for ASCVD
but we are advised not to treat.
The recommendations include the use of body mass index as "a quick and easy first screening step" to identify patients who may be at risk for obesity-related health problems, and waist circumference as an indicator of ASCVD
risk, type 2 diabetes, and all-cause mortality, Dr.
When everyone accepts that treatment for cholesterol damage is as effective and as important as treatment for high blood pressure, fewer people will die of the complications of ASCVD