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ATF2Activating Transcription Factor 2
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The study, demonstrates that the MITF is subject to negative regulation by ATF2, and such regulation is a key determinant in melanoma development.
This work also reveals that the ratio of ATF2 to MITF in the nucleus of melanoma cells can predict survival in melanoma patients - relatively high amounts of ATF2 and correspondingly low MITF levels were associated with a poor prognosis.
disrupted the ATF2 gene in the melanocytes of mice harboring mutations often seen in human melanoma.