ATF6Activating Transcription Factor 6
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In contrast to ATF4 levels, the level of ATF6 detected at 90 kDa was not changed, and its 50-kDa fragment did not appear after 2-24 hr of exposure (data not shown).
In the present study, although the levels of the cleaved and the uncleaved forms of ATF6 were not changed (data not shown), ATF4 protein levels increased dramatically with increased time of exposure to Cd[Cl.
XBP1 is also induced by activated ATF6 (Activating Transcription Factor 6) (Yoshida et al.
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor.