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ATIIIAntithrombin III (anticoagulant)
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Ademas, la union de la trombina a la TM hace que esta proteasa sea mas sensible a la inhibicion por la ATIII, en comparacion con la trombina libre.
The assays were performed on a Stago STA-Compact[R] with STA[R] System Controls N&P, STA[R] Neoplastine CI+, STA[R] PTTA, STA[R]--Fibrinogen, STA[R] Liatest[R] Controls N&P, STA Liatest[R] VWF (Immuno-turbidimetric) and STA[R] Stachrom[R] ATIII (Functional-Chromogenic) reagents.
ATIII deficiency is common in glomerular diseases due to protein loss (DiBartola and Meuten 1980, Greco and Green 1987, Cook and Cowgill 1996, Ritt et al 1997).
The following thrombogenic factors probably contribute to this association: acquired protein C and protein S deficiencies, elevated plasma fibrinogen, impaired fibrinolysis, depressed ATIII, reactive thrombocytosis, increased platelet aggregation, and antiphospholipid antibodies.
Por otro lado, esta misma condicion no altera el tiempo de tromboplastina parcial activado (TTPA) (9,26), los niveles de ATIII o de proteina C (1).
3 mg/dL), urea 132 mg/dL (10-45 mg/dL), D-dimere 1,558 [micro]g/L (<200 [micro]g/L), ATIII 67% (>75%), creactive protein (CRP) 237 mg/L (<9 mg/L), lactate dehydrogenase (LDH) 322 U/L, and slightly elevated liver enzymes.
ATIII is the protein normally found in human plasma that helps regulate blood clotting.
Anticoagulants Anti-thrombin III Agonists: Heparin, Low Molecular Weight Heparin, ATIII Inhibitors of Factor IIa (Thrombin) Inhibitors of Factor Xa Dual Inhibitors of Factor IIa and Xa Inhibitors of Factor IXa Inhbitors of Factor VII/Tissue Factor Inhibitors of Factor VIII Antiplatelet Agents Inhibitors of Platelet ADP Receptor Inhibitors of PAR-1 / Thrombin Receptor Antagonists of GPIIb/IIIa Antagonists of GPIb & von Willebrand Factor Antagonists of GPVI Antithrombotics