AUC0-24area under the curve during 24 hours
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Rofecoxib produced no evidence of significantly delayed labor or parturition in females at doses 15 mg/kg in rats (approximately 10- and 3-fold human exposure as measured by the AUC0-24 at 25 and 50 mg).
The dose tested represents an approximate 18- and 6-fold human exposure at 25 and 50 mg based on AUC0-24.
05 mg/kg/day and an assumption of 100% absorption, the maximum theoretical plasma AUC0-24 hrs for penciclovir is approximately 0.