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AUC0-24

    0.01 sec.
AcronymDefinition
AUC0-24area under the curve during 24 hours


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Imitrex Tablets, formulated with RT Technology, are bioequivalent to conventional Imitrex Tablets as measured by AUC0-24 and Cmax.
Nonteratogenic effects: Rofecoxib produced peri-implantation and post-implantation losses and reduced embryo/fetal survival in rats and rabbits at oral doses greater than or equal to 10 and greater than or equal to 75 mg/kg/day, respectively (approximately 9- and 3-fold [rats] and 2- and less than 1-fold [rabbits] human exposure based on the AUC0-24 at 25 and 50 mg daily).
Nonteratogenic effects: Rofecoxib produced peri-implantation and post-implantation losses and reduced embryo/fetal survival in rats and rabbits at oral doses greater than or equal to 10 and greater than or equal to 75 mg/kg/day, respectively (approximately 9- and 3-fold [rats] and 2- and less than 1-fold [rabbits] human exposure based on the AUC0-24 at 25 and 50 mg daily).
 
 
 
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