Infertilite olgularinin 4'unde (%3,48) AZFa, 2'sinde (%1,74) AZFb, 3'unde (%2,61) AZFc ve 7'sinde (%6,09) AZFd bolge delesyonu saptandi.
AZF bolgesi AZFa (proksimal), AZFb (orta), AZFc (distal) ve AZFd (AZFb ve AZFc arasi) seklinde birbiri ile ortusmeyen dort alt bolgeye ayri1maktadir.
The MLPA probe design for this probemix was complicated by the presence of an inverted tandem duplication in AZFc which contains many of the important spermatogenesis genes.
Of the 50 infertile men that were analyzed, four (8%) were found to have a microdeletion of some part of the AZFc region (see tables 1 and 2) whilst one individual (2%) had a microduplication of AZFc.
Individual deletions in AZFb and AZFc regions were detected in 6 and 1 of the patients which accounted for 50 and 8.
It has been suggested that AZFc is the most frequently deleted region (60%), followed by deletions of the AZFb and combined deletions involving different AZF regions (35%).
In 10 of the cases AZFc deletion, in 1 case AZFb deletion and in 1 case both deletions were identified.
Daha sonra yapilan Calismalarla ise AZFa, AZFb, AZFc ve son olarak AZFd bolgeleri ayri ayri gosterilmistir (Sekil 1).
The increase of primary spermatocytes was particularly shown in AZFb and AZFc microdeletions (9,10), but with fundamentally different meiotic pictures.
Meiotic abnormalities in patients beating complete AZFc deletion of Y chromosome.
In the AZF region, three loci termed as AZFa, AZFb and AZFc have been identified.
However, deletion of only AZFc region is found to be associated with a wide range of phenotypes ranging from hypospermatogenesis to SCO II (isolated foci of spermatogenesis along with Sertoli cells) syndrome (9).