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His acute renal failure (Table 1) was treated
with hemodialysis; it was attributed to acute tubular necrosis from
dehydration and intravascular hemolysis, superimposed on chronic renal
insufficiency from hypertensive nephrosclerosis. Prophylactic or therapeutic dosing
with FG-4539 improved renal function as evidenced by lower BUN and serum
creatinine levels, improved GFR, and prevented acute tubular necrosis as
confirmed by histological analysis. Complications during her hospitalization unrelated to babesiosis
included nosocomial pneumonia, acute tubular necrosis from
hypoperfusion, bilateral deep venous thromboses, pulmonary embolism, and
thrombocytopenia temporally associated with the initiation of heparin
therapy (Table). |
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