Ad8Adenovirus Type 8
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He led efforts to develop a number of dementia screening tools in addition to the QDRS and AD8, and has done cross-cultural validation of dementia screening methods in comparison with Gold Standard clinical evaluations and biomarker assays.
Overall, the AD8 has proved more useful than the Mini Mental State Examination in picking out patients with the very earliest signs of cognitive impairment, Dr.
Because it provides a picture of change related to baseline, the AD8 avoids the problem of a "snapshot" test, which could, for example, falsely identify cognitive problems in someone who has never had a good memory.
The AD8 asks informants to answer yes, no, or don't know to whether the patient has changed in eight areas: problems with daily judgment and decision making; decreased interest in hobbies or activities; repeating things over and over; trouble learning how to use a new tool or appliance; forgetting the month or year; trouble with financial affairs; trouble recalling appointments; and daily problems with thinking and memory.
Patients with a positive AD8 are significantly more likely to have brain atrophy in the temporal lobe, hippocampus, and parahippocampal gyrus than are those with a negative screen.
A positive AD8 will most likely mean additional tests for the patient, including brain imaging, biomarkers, neuropsychological testing, and other diagnostic activities.
Validation studies of the AD8 have confirmed that it can identify early changes in a plethora of dementias, including Alzheimer's disease and progressive aphasias, as well as Lewy body, frontotemporal, and vascular dementia.
According to Galvin, who was lead investigator of the study, "The Area Agency on Aging staff reported the AD8 was easy to administer, useful to detect cognitive impairment and made it easier to discuss memory loss with clients.
Based on our results, the AD8 appears to be superior to conventional testing in its ability to detect signs of early dementia.