3 is an alternative to V-RG that might have a different human safety profile given the high prevalence of antibodies in humans to human adenovirus type 5 and the mild illness that typically results from infection with this virus (7).
An oral rabies vaccine consisting of a recombinant human adenovirus type 5 vector (AdRG1.
Although the difference in infection rates between the vaccine and placebo groups across the entire study population was only "marginally statistically significant," in the subgroup of participants with high levels of adenovirus type 5
(Ad5) immunity--defined as antibody levels greater than 200 U--the statistical significance between the two groups was more robust.
6 ITR-MCS containing the VP2, the pRC-CMV expressing the Rep and Cap coding regions of AAAV  and a commercial pHelper plasmid coding for the E2, E4 and VR-RNA genes derived from the human adenovirus type 5
(Stratagene, La Jolla, CA.
The complete nucleic acid sequence of the adenovirus type 5
reference material (ARM) genome.
The functions of E4 ORF 6/7 peptides of Ad7 are unknown, but the corresponding protein of adenovirus type 5
has the ability to induce the binding of cellular transcription factor E2F to the viral E2a promoter region (26).