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, breast, ovarian, testicular), cardiovascular
disease, osteoporosis, and age-related cognitive decline. These men and
women, ranging in age from 30 to 85, suffered from age-related disorders
including: general anxiety; depression; reduced energy, vitality and sex
drive; overall progressive decline in mental acuity ranging from mild
cognitive impairment to age-related cognitive decline and age-associated
memory impairment; and menopause/andropause symptomology which, in some
cases, was accompanied by unpredictable, hormonally induced mood swings. By allowing comparisons between genes expressed in young,
"normal" old, and memory-impaired old rats, the model produces
a comprehensive profile of age-related cognitive decline, rather than an
analysis of a single suspected mechanism or process. |
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