| Acronym | Definition |
|---|
| AFCS | Automatic Flight Control System |
| AFCS | Adobe Flash Collaboration Service |
| AFCS | Alliance for Cellular Signaling |
| AFCS | Armed Forces Compensation Scheme (UK MoD) |
| AFCS | Air Force Communications Service |
| AFCS | Automatic Fire Control System |
| AFCS | Advanced Facer Canceller System (USPS) |
| AFCS | American Friends Service Committee (Quakers) |
| AFCS | Advanced Flight Control System |
| AFCS | Army Facilities Components System |
| AFCS | Advanced Facer Canceler System (Postal Service) |
| AFCS | Australian Forest Certification Scheme |
| AFCS | Active Federal Commissioned Service |
| AFCS | Armed Forces Courier Service |
| AFCS | Aircraft Flight Control System |
| AFCS | Automated Fire Control System (US DoD) |
| AFCS | Air Force Corporate Structure |
| AFCS | Atlanta Fulton County Stadium |
| AFCS | Advanced Fire-Control System |
| AFCS | Advanced Fuel Cell Systems |
| AFCS | Adaptive Fire Control System |
| AFCS | Allied Forces Contingency Stock |
| AFCS | Air Force Communications System |
| AFCS | Senior Chief Aircraft Maintenanceman (Naval rating) |
| AFCS | Automatic Facilities Control Subsystem |
| AFCS | Artillery Fire Control Systems |
| AFCS | Air Force Comprehensive School (Nigeria) |
| AFCS | American Financial Credit Services, Inc. (Indiana and Florida; est. 1993) |
| AFCS | Agriculture, Forestry and Consumer Sciences (West Virginia University) |
| AFCS | All Florida Contracting Services (Coral Springs, FL) |
| AFCS | Alkourashi's First Class Squad (gaming) |