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ADE |
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Antibody-dependent enhancement of dengue virus growth in human monocytes as a risk factor for dengue hemorrhagic fever. In a potentially worrisome finding anticipated by some researchers, blood taken f rom six vaccine recipients showed signs of "complement-mediated antibody-dependent enhancement. Furthermore, the nonneutralizing antibodies are known to facilitate viral infection, termed antibody-dependent enhancement (ADE), which is the pathogenic basis of feline infectious peritonitis virus (FIPV, a type II coronavirus), dengue hemorrhagic fever, and other viruses (34-36,37). |
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