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ADCC |
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We have previously shown that the same gE epitope is involved in both complement-dependent neutralization (12) as well as antibody-dependent cellular cytotoxicity (13). Seattle Genetics has demonstrated that SGN-70 possesses potent antitumor activity in preclinical models of both hematologic malignancies and carcinomas, including complement-dependent cytotoxicity, antibody-dependent cellular phagocytosis and antibody-dependent cellular cytotoxicity. In vitro, ERBITUX can mediate antibody-dependent cellular cytotoxicity (ADCC) against certain human tumor types. |
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