15,16) Thus, although there has been a modest improvement in ARL survival from approximately 11 to 22 months since the advent of HAART, this effect is most likely because of a change in tumor biology resulting from immune preservation that gives rise to an environment in which lymphomas develop from a germinal center origin with greater treatment sensitivity.
was among the first to suggest that low-dose chemotherapy may not necessarily be the best treatment in all ARL cases.
In considering this question, it is worth keeping in mind that recent studies of a variety of regimens have shown improving response to ARL and that adding therapeutic agents (such as HAART) to a regimen has the possibility of increasing toxicity.
Taking a somewhat different approach to this question Of whether to combine HAART with therapy for ARL, our group at the National Cancer Institute has explored the use of infusional dose-adjusted EPOCH (etoposide, doxorubicin, vincristine, cyclophosphamide, and prednisone) chemotherapy in ARL with HAART temporarily withheld during the period of EPOCH treatment.
3]) and the disease-free survival of 92% at 52 months of follow-up demonstrated that a desirable outcome in the therapy of ARL is not dependent on concomitant HAART administration during chemotherapy.
The comments above apply to systemic ARL in which therapy is administered for curative intent.
For example, the Federal State Cooperative System (FSCS) managed by the National Center for Education Statistics (NCES) collects annual public library data focused on approximately fifty data elements; NCES also manages data collection activities for academic and school libraries through its library statistics program; ARL collects annual statistics from its members and so too does the Association of College Libraries (ACRL); and, as a final example, the Public Library Association collects annual statistics from a sample of public libraries through its Public Library Data Service (PLDS) program.
If ARL libraries are any indicator of what is happening in libraries in terms of electronic materials expenditures, then libraries are in the process of dramatically altering their collections to the point of redefining collections development and acquisitions processes.
According to the ARL data presented above, nearly 20 percent of library materials budgets is for electronic resources.
ARL has approximately 120 academic library members.
Measures and statistics for research library networked services: Procedures and issues: ARL e-metrics phase II report.