BRCA-1, for example, interacts with a partner protein known as BARD1
(BRCA-1-associated ring domain).
Robust examples from the multiple case-control association studies of common variants include a missense arginine to histidine amino acid change (D302H) in CASP8 associated with a moderate reduction in breast cancer risk , a common amino acid change (C557S) in BARD1
which increased breast cancer risk , and most recently a variant in RASSF1A associated with early-onset cancer in BRCA1 and BRCA2 mutation carriers .
In 2009, Maris published two more gene studies, identifying common variants in the gene BARD1
and copy number variants on chromosome 1 that raised the risk of neuroblastoma.
deCODE has linked a variant within a gene called BARD1
(BRCA1-associated RING domain 1) to increased risk of breast cancer in the general population.
the gene-encoding leukotriene A4 hydrolase, linked to heart attack; -- the gene-encoding transcription factor 7-like 2 (TCF7L2), linked to type 2 diabetes; -- the gene encoding BARD1
, linked to breast cancer.