In this section, we will see how the BCRP
determines its policy interest rates and what impact does this have on the banking system.
Inverted plasma membrane vesicles (so called 'inside-out' vesicles) are usually used to study the ATP-dependent ABC efflux transporters such as P-gp, BCRP
Although these studies did not measure P-gp or BCRP
expression, it is possible that the observed synergy results from lapatinib-mediated P-gp/BCRP
inhibition, which prevents drug efflux and increases drug-induced cell death.
Determination of BCRP
Activity and Evaluation of Potential BCRP
-Mediated Drug-Drug Interactions in Caco-2 Cells Using the Fluorescent Substrate Pheophorbide A (Poster #T2392) Author: Ying Wang, et al.
and MRP1), only P-gp was found to be overexpressed in SW620 Ad300 cells (Lai et al.
says that the annualized growth rate for the country in the period January 2006 through August 2006 was 7.
The main aim of the BCRP
is to prevent and deter crime from happening in the first place, rather than focusing on arrests and prosecution.
Of the three, MRP1 had the highest expression rate, at 81% across all tumor types, followed by BCRP
at 66%, and PGP at 23%.
Results: P-glycoprotein- or BCRP
overexpressing tumor cells did not reveal cross-resistance to reserpine.
Specific transporter proteins, BCRP
is one example, have been identified by regulatory agencies such as the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) as key mediators of unintended drug interactions*.
Caution should be exercised when ataluren is coadministered with medicinal products that are substrates or inducers of UGT1A9, inhibitors of BCRP
, or substrates of OAT1, OAT3, or OATP1B3.
P-glycoprotein- overexpressing CEM/ADR5000 cells were not cross-resistant to honokiol, but MDA-MB-231 BRCP cells transfected with another ABC-transporter, BCRP
, revealed 3-fold resistance.