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BH3Bcl-2 Homology 3
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Led by principals Gregory Freedman, Charles Phelan, and Daniel Lebensohn -- BH3 is an opportunistic real estate firm with a core focus on acquiring real estate in South Florida and New York City.
Gene name Gene description MAP3K7 Mitogen-activated protein kinase kinase kinase 7 HDAC9 Histone deacetylase 9 CFTR Cystic fibrosis transmembrane conductance regulator ETHE1 Ethylmalonic encephalopathy 1 MCM3AP Minichromosome maintenance deficient 3 associated protein SPIB Spi-B transcription factor WT1 Wilms' tumor 1 BID BH3 interacting domain death agonist C1QTNF3 Clq and tumor necrosis factor related protein 3 S0D2 Superoxide dismutase 2 SFRS1 Splicing factor, arginine/serine-rich 1 UBE2N Ubiquitin-conjugating enzyme E2N Gene name Glycyrrhizin Silymarin Change (folds) FDR Change (folds) FDR MAP3K7 -5.
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.
Most notably, the BH3 mimetic has the highest affinity for BCL2, BCL-XL, and BCL-W, but only a poor affinity for MCL1 and BCL2A1.
The anti-apoptotic members of the Bcl-2 family contain four homology domains, BH1, BH2, BH3, and BH4 (Janumyan et al.
By restoring the bioactive shape of the BH3 signaling peptide, the hydrocarbon stapling technology not only generated the compound to achieve this discovery, but provides the first drug candidate to target this site for therapeutic purposes," said Loren Walensky, M.
June 9, 2015 /PRNewswire/ -- Prive Developers, LLC , led by co-developers BH3 and Gary Cohen as Principal, announced today that Prive at Island Estates is now in its second month of foundation construction.
Bax is a pro-apoptotic member of the Bcl-2 protein family that contains BH1, BH2, and BH3 domains (Oltvai et al.
Loren Walensky, developed a compound modeled directly from the pro-apoptotic the death domain of BCL-2, the BIM BH3 domain.