Similarly, the use of rescue medications was lower in those who received BIBN 4096 BS than in those who received placebo.
At all dose levels, the difference in response between BIBN 4096 BS and placebo became evident within 30 minutes of starting the infusion.
To date, studies have shown that BIBN 4096 BS has "no constrictor effect on the middle cerebral, radial, or superficial temporal artery or on regional cerebral blood flow, blood pressure, or heart rate.
Unlike migraine drugs that constrict blood vessels, BIBN
4096 BS doesn't seem to affect blood vessels in the heart or elsewhere outside the brain, says Paul L.