Chimerix's lead candidate, CMX001, is a novel, broad spectrum nucleoside analog that is anabolized intracellularly and inhibits double-stranded DNA (dsDNA) viruses including CMV, adenovirus (AdV), BKV
, and herpes simplex virus.
In immunocompetent populations, high seroprevalence values of 82%-98% for BKV
(19-22) and 39%-77% for JCV (19-22) have been reported.
Plasmid containing the complete human BKV
genome cloned into the vector pBR332 was purchased as a bacterial stock (American Type Culture Collection [ATCC], Manassas, Virginia), prepared using QIAfilter Plasmid Midi Kit (Qiagen, Valencia, California), and quantified spectrophotometrically (BioMate 5 UV-visible spectrophotometer, Thermo Spectronic, Altham, Massachusetts).
The company's new glass fiber-reinforced nylon, PA 6 Durethan BKV
EF (Easy Flow), is said to offer approximately 50% higher flowability than a comparable standard PA 6, with no adverse effects on the elasticity modulus, stiffness, elongation at break, or flow-line strength.
Untreated urine (5 [micro]L; diluted 1:10 in distilled water) was examined with a quantitative TagMan PCR assay that detects BKV
as well as JCV.
Organizations like BKV
Group use Circadence WAN and network optimization solutions for rapid, reliable and secure transfer of data.
It's clear that mobile is a key piece of the marketing mix for today's companies," said Kelley Haas, chairman, BKV
The severity of diseases caused by BKV
and JCV (5,6,15) raises the question of whether WUPyV and KIPyV can cause human disease.
The WW BKV
strain, which consists of O (142 base pairs [bp]), P (63 bp), Q (39 bp), R (63 bp), and S (63 bp) of the TCR region, has been called archetypal by Sugimoto et al, (10) and any deviation from this structure is considered a rearranged form, (11) including single nucleotide polymorphisms and the deletion, insertion, or duplication of blocks of sequences (major rearrangements).
Leveraging the flexible integrations offered by Marin, BKV
is more efficiently managing and optimizing online campaigns for clients.
DNA has been detected in blood of renal transplant patients, and BKV
load may be predictive of polyomavirus-associated nephropathy (10).
RMI is a sister company to BKV
Advertising and operates under the BKV
umbrella of direct marketing companies.