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BMAL1 |
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Schibler and colleagues report similar results, demonstrating that SIRT1 levels rise and fall throughout the day, and that SIRT1, CLOCK and BMAL1 interact in a circadian manner. A modification in a single amino acid in the BMAL1 protein activates the genetic processes involved with circadian rhythms, the researchers found. In a paper appearing in the 21 November issue of Science Express, Rutter and others show that exposure to carbon monoxide affects NPAS2's ability to bind with a clock protein called BMAL1, which in turn affects the expression of certain circadian cycle genes. |
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