BMP2Bone Morphogenetic Protein 2
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BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway.
Positive staining for BMP2 was found in the matrix adjacent to the tumour cells and also in areas of developing bone formation with osteoblast-like cells (Fig.
Signaling, or messaging, initiated by BMP2 and targeted to other bone-forming molecules along the BMP2 signaling pathway "is absolutely essential for building and reforming bone," Chen says.
BioMimetic Therapeutics will launch its Augment Bone Graft product in Australia in 2012 and Korea Bone Bank expects to be on the market with its Rafugen BMP2 DBM Gel in South Korea in 2014, the latter marking only the third bone morphogenetic protein product available worldwide.
He also will disclose new data on the cell lines: SK17 that have the potential to differentiate into cells that express renin and smooth muscle cell-related genes characteristic of the juxtaglomerular apparatus of the kidney, Z2 that when differentiated using a proprietary protocol expresses relatively high levels of the bone growth factor genes BMP2 and BMP7 (also known as osteogenic protein-1 (OP-1), and J16 that expresses preadipocyte markers of interest to researchers in cosmetic dermatology and type II diabetes.
For example, BMP2 can enhance TGF-13 induced initial phenotypic changes associated with endothelial-mesenchymal transformation during generation of the valvuloseptal endocardial cushion formation (Nakajima et al.
The genes include BMP2 and BMP4, which are now the focus of additional research.
Currently, two BMPs, BMP2 and BMP7, are prepared for clinical use combined with collagen carriers.
Other BMP products under development include Genetic Institute's BMP2 and Stryker Biotech's OP-1.
Besides, it has been proved that Runx2 expression was stimulated by BMP2 treatment (Otto et al.
Both PGE2 and BMP2 are normally induced at sites of bone injury and the inhibition or lack of cyclooxygenase 2 (COX2), which is required for synthesis of PGE2 is known to dramatically impair fracture healing.