BMPR2


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AcronymDefinition
BMPR2Bone Morphogenetic Protein Receptor-II
References in periodicals archive ?
Selten's SPI-026 program is an investigational BMPR2 (Bone morphogenetic protein receptor type II) pathway activator being evaluated for the treatment of patients with pulmonary arterial hypertension.
Mutations of theTGF-beta type II receptor BMPR2 in pulmonary arterial hypertension.
Machado RD, Pauciulo MW, Thompson JR, et al: BMPR2 haploinsufficiency as the inherited molecular mechanism for primary pulmonary hypertension.
Heterozigot BMPR2 mutasyonu fenfluramine bagli ve konjenital kalp hastaligina gelisen PAH olgularmin ufak bir bolumunde saptanmistir (7,8).
BMPR2 mutasyonu olan olgularm kalsiyum kanal blokerleri ile tedaviden yarar gormesinin olasi olmadigi bildirilmistir (9).
BMPR2 normal akcigerlerin arter duz kas hucrelerinde hucre cogalmasini baskilar, apoptozisi stimule eder.
IPAH hastalarinda, kalitsal PAH hastalarina gore cok daha az oranda saptanan BMPR2 (kemik morfogenetik protein reseptoru tip 2) mutasyonu tasiyicisi PAH hastalarinin, mutasyonu olmayan hastalara gore, PVT yanitlarinin anlamli sekilde daha fazla negatif bulundugu saptanmistir (%1.