BNIIBehring Nephelometer II Analyzer
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We performed a method comparison of 4 automated cystatin C assays: Siemens N Latex Cystatin C on a BNII, Roche Tina-quant Cystatin C and Genzyme Cystatin C on a Roche Cobas c501, and Tosoh ST AIA-PACK Cystatin C on a Tosoh AIA-600II (Table 1).
We carried out the nephelometric technique on a BNII analyzer (Siemens) using Freelite[R] reagents (The Binding Site) according to the manufacturer's instructions.
We measured cystatin-C using a particle-enhanced immunonephelometric assay (N Latex cystatin-C; Dade Behring) with a nephelometer BNII (Dade Behring).
Finally, given the fact that this is a cross-sectional, observational study, no firm conclusions can be made with regard to the mechanisms behind the associations between BNII and age and GFR and NT-proBNP.
Our data indicate that NT-proBNP reflects cardiorenal function (29), a finding that suggests a reasonable physiological explanation--the level of GFR-for the relationship between age and plasma concentrations of NT-proBNP and the relationship between BNII and plasma concentrations of NT-proBNP in CHF patients.
We had previously shown (data not included) that the IMMULITE and Integra CRP methods correlated very well with the BNII.
Our findings suggest that in people with type 2 diabetes, BNII is associated with worse glycemic control and dyslipidemia only among those with high-normal GGT, but not in those with low-normal GGT.
High-sensitivity CRP (Hs-CRP) was assayed with the particle-enhanced immunonephelometry system on the Dade Behring BNII analyzer (bade Behring).