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BRAF |
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Tokyo, Japan, Feb 13, 2006 - (JCN) - The Tohoku University Graduate School of Medicine has discovered that two different oncogenes KRAS and BRAF play a key role in the occurrence of cardiofaciocutaneous (CFC) syndrome. Although these predominantly male risk factors correlate with and may at least partially explain the higher incidence of melanoma in males versus females, the mechanism behind this sex-linked effect remains unclear, as does the role of BRAF aberrations in the etiology of melanoma. The investigators found BRAF mutations in a range of other human cancers, although the gene alterations weren't as frequent. |
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