It is the first time any drug has been approved to treat certain patients with metastatic breast cancer who have a BRCA
Under the International guidelines of ESMO, ASCO and NCCN, the partnership has been recommended to use the BRCA
testing, which will provide patients and doctors with important information on disease prognosis and may improve treatment decisions.
Triple-negative breast cancer patients with a BRCA
mutation might have a survival advantage in the first few years following diagnosis, compared with non-BRCA
carriers, the POSH study also found.
Prof Peter Fasching, of Friedrich-Alexander University Erlangen-Nuremberg, Germany, said of the research: "Patients with BRCA
mutations are at increased risk of developing secondary cancers.
The study found that there was no difference in overall survival two, five or ten years after diagnosis for women with and without a BRCA
mutation," a press statement said.
The healthy cells of people who have BRCA
mutations lack one copy of the BRCA
About 15 per cent of cases of ovarian cancer are linked to BRCA
, which means the test could potentially save the lives of more than 1000 women a year in the UK.
What saddens Goldberg is the fact that as of today, preventive options for BRCA
1 and 2 cancers are limited to radical, life-altering prophylactic surgeries, like mastectomies and removal of ovaries for women.
20]Kauff ve arkadaslarinin  (2002), 170 BRCA
mutasyon tasiyicisi olan hastalardan 98'ine yapilan PBSO cerrahisi sonrasinda, BRCA
ile iliskili jinekolojik kanser riskinde azalma oldugu belirtilmistir.
WOMEN with ovarian cancer and mutations to their BRCA
genes are still not being granted a "world-first drug" on the NHS, something the chief executive of the Institute of Cancer Research has said is "disappointing".
Olaparib is intended for use in women who have an abnormal BRCA
gene and have previously been treated with chemotherapy.
Haider Kamran Chaudhary was leading the delegation which included Irfan Tariq, Aamir Khan and Tariq Sarwar.