Also found in: Dictionary, Thesaurus, Medical, Encyclopedia, Wikipedia.
Related to BRCA1: BRCA2
BRCA1Breast Cancer Gene 1
References in periodicals archive ?
BRCA1 is a key protein involved in DNA repair, and mutations that impair its function increase the risk for breast and ovarian cancer.
Actress Angelina Jolie this year announced she had decided to have her ovaries removed after finding she has a faulty copy of the BRCA1 gene.
Among the study participants with BRCA1 mutations, 9,052 women (46%) developed breast cancer, 2,317 (12%) developed ovarian cancer, and 1,041 (5%) developed both breast and ovarian cancer.
Lead researcher Professor Martin Widschwendter, from University College London, said: "We identified an epigenetic signature in women with a mutated BRCA1 gene that was linked to increased cancer risk and lower survival rates.
Indeed, it would be premature at this point to recommend routine hysterectomy along with RRSO women with BRCA1 mutations; the decision regarding hysterectomy at the time of RRSO may depend on the patient's age, prior cancer history, and other risk factors, senior author Dr.
Once they established that the two proteins complex together, they sought to answer if BRCA1 plays a critical role in regulating muscle metabolic function.
Among patients with breast cancer and a significant family history of cancer who test negative for BRCA1 and BRCA2, approximately 12% can be expected to carry a large genomic deletion or duplication in one of these genes.
We were interested in families with BRCA1 and BRCA2 mutations and tested more than 1,000 breast cancer patients who self-identified as Ashkenazi Jews.
This supports selected in vitro and in vivo pre-clinical data which shows that heterozygosity for BRCA1 or BRCA2 in a carrier's normal tissues does not manifest as an increase in toxicity due to intrinsic HR deficiency.
The researchers deleted the BRCA1 gene in both mouse basal stem cells and luminal intermediate cells.
Defective BRCA1 and BRCA2 genes also account for about 10% of ovarian cancers, and in men BRCA2 is believed to increase the risk of early-onset prostate cancer.
2) Two tumour suppressor genes involved in early-onset breast and ovarian cancer, BRCA1 and BRCA2, have been mapped and cloned.